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Noradrenaline tartrate

CAS No. : 51-40-1

MCE 站：Noradrenaline tartrate

产品活性：Norepinephrine tartrate (Levarterenol tartrate) 是一种天然的应激激素和神经递质，是 β₁ 选择性的adrenergic receptor激动剂，EC₅₀值为 5.37 μM。

研究领域：Metabolic Enzyme/Protease  |  Neuronal Signaling  |  GPCR/G Protein  |  Autophagy

作用靶点：Endogenous Metabolite  |  Adrenergic Receptor  |  Autophagy

In Vitro: Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β₁-subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β₂-adrenoceptor in higher concentrations.
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 ?M) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.

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