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Setmelanotide acetate

CAS No. : 1504602-49-6

MCE 站：Setmelanotide acetate

产品活性：Setmelanotide acetate (RM-493 acetate) 是一种黑皮质素 4 受体 (MC4R) 激动剂，作用于人和大鼠 MC4R，EC₅₀ 分别为 0.27 nM 和 0.28 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Melanocortin Receptor

In Vitro: Melanocortin receptor agonists act in the brain to regulate food intake and body weight. Setmelanotide exhibits agonist activity to human and rat MC4R with K_is of 2.1 and 2.7 nM and EC₅₀s of 0.27 and 0.28 nM, respectively.

In Vivo: Inhibition of refeeding after an overnight fast by Setmelanotide (BIM-22493) is dependent on functional MC4R, and does not require MC3R. Setmelanotide acutely improves glucose homeostasis. Lep^ob/Lep^ob mice treated with Setmelanotide exhibits significantly improved glucose clearance when compared to controls. Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model.

相关产品：α-Melanocyte-Stimulating Hormone (MSH), amide  |  Bremelanotide Acetate  |  SHU 9119  |  THIQ  |  Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA  |  ACTH (1-17) (TFA)  |  Nonapeptide-1 acetate salt  |  ACTH (11-24)  |  SNT-207707  |  β-Melanocyte Stimulating Hormone (MSH), human TFA  |  HS014  |  HS024  |  JKC363  |  ML-00253764 hydrochloride  |  MSG606  |  Neuropeptide EI, rat  |  PG-931  |  PG106  |  Terrein  |  [D-Trp8]-γ-MSH  |  γ1-MSH

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