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Pseudocoptisine chloride

CAS No. : 30044-78-1

MCE 站：Pseudocoptisine chloride

产品活性：Pseudocoptisine (Isocoptisine) chloride 是一种具有苄基异喹啉骨架的季生物碱。Pseudocoptisine chloride 可抑制乙酰胆碱酯酶 (AChE) 活性，IC₅₀ 为 12.8 μM。具有抗发炎和健忘作用。

研究领域：Neuronal Signaling

作用靶点：AChE

In Vitro: Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.

In Vivo: The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test.

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