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Mitomycin C

CAS No. : 50-07-7

MCE 站：Mitomycin C

产品活性：Mitomycin C (Ametycine) 是一种 DNA 交联剂 (DNA cross-linking agent)，诱导 DNA 损伤。Mitomycin C 是一种抗肿瘤化合物和抗生素，可有效的抑制 DNA 合成 (DNA synthesis)。Mitomycin C 是一种 ADC 毒性分子 (ADC Cytotoxin)，可以诱导凋亡 (Apoptosis) 作用。

研究领域：Cell Cycle/DNA Damage  |  Antibody-drug Conjugate/ADC Related  |  Anti-infection  |  Apoptosis

作用靶点：DNA Alkylator/Crosslinker  |  DNA/RNA Synthesis  |  ADC Cytotoxin  |  Bacterial  |  Apoptosis  |  Antibiotic

In Vitro: The HCT116 (p53^-/-) cells are minimally sensitive to either Mitomycin C (Ametycine) or TRAIL alone. However, surprisingly, combination treatment with MMC and TRAIL decreases cell viability significantly. Although Mitomycin C and TRAIL alone are moderately effective, Mitomycin C substantially enhances the effect of TRAIL on suppression of the cell proliferation. Mitomycin C and TRAIL treatment alone induces 9.5% and 35.0% apoptosis, respectively. However, combination treatment with Mitomycin C and TRAIL enhances apoptosis to 66.6%.
Mitomycin C is a cytotoxic chemotherapeutic agent that causes DNA damage in the form of DNA cross-links as well as a variety of DNA monoadducts and is known to induce p53.

In Vivo: Mice bearing xenografted HCT116 (p53^-/-) colon tumors and HT-29 colon tumors are treated with Mitomycin C (Ametycine; i.p., 1 mg/kg) and TRAIL (i.v., 100 μg) every other day. Animals are treated with 10 consecutive cycles of the combination therapy regimen. The combination therapy suppresses tumor growth significantly and does not impact the weight of the mice, indicating that the therapeutic combination of Mitomycin C and TRAIL is well-tolerated and has anti-tumor activity in vivo.
Intravesical Mitomycin C instillations has an effect on body weight. After 3 consecutive weekly instillations of 1 mg/mL Mitomycin C there is almost no weight gain, whereas rats in the other 3 groups has a statistically significant weight gain compared with MMC treated rats.

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