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Actinomycin D

CAS No. : 50-76-0

MCE 站：Actinomycin D

产品活性：Actinomycin D (Dactinomycin) 抑制 DNA 修复，IC₅₀ 为 0.42 μM。Actinomycin D 是一种自噬 (autophagy) 激活剂。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Anti-infection  |  Apoptosis

作用靶点：DNA/RNA Synthesis  |  Autophagy  |  Bacterial  |  Apoptosis  |  Antibiotic

In Vitro: Actinomycin D (Dactinomycin) is an inhibitor of DNA transcription and replication. Actinomycin D markedly reduces the vascular smooth muscle cells (SMC) proliferation via the inhibition of BrdU incorporation at 80 nM. This is further supported by the G1-phase arrest using a flowcytometric analysis. Actinomycin D is extremely potent with an inhibitory concentration IC₅₀ at 0.4 nM, whereas the lethal dose LD50 is at 260 microM. The protein expression levels of proliferating cell nuclear antigen (PCNA), focal adhesion kinase (FAK), and Raf are all suppressed by Actinomycin D. Extracellular signal-regulated kinases (Erk) involved in cell-cycle arrest are found to increase by Actinomycin D.

In Vivo: The pluronic gel containing 80 nM and 80 μM Actinomycin D (Dactinomycin) is applied topically to surround the rat carotid adventitia, the thickness of neointima is substantially reduced (45 and 55%, respectively). Mice in the Actinomycin D and NSC 118218 group lives significantly longer than the control group with P values of <0.001 and 0.007, respectively. Interestingly, single treatment with Actinomycin D is superior to NSC 118218 regarding overall survival (P=0.026).

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