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Digoxin

CAS No. : 20830-75-5

MCE 站：Digoxin

产品活性：Digoxin是 Na+/K+-ATPase 的有效抑制剂，有潜力用于心律失常和心力衰竭的研究。

研究领域：Membrane Transporter/Ion Channel  |  Metabolic Enzyme/Protease

作用靶点：Na+/K+ ATPase  |  Endogenous Metabolite

In Vitro: Digoxin, a sodium-potassium ATPase inhibitor, has a negative Z score of ?26.67, suggesting a function for the sodium-potassium ATPase in CHIKV infection. Relative to DMSO-treated cells, treatment of U-2 OS cells with Digoxin results in a dose-dependent decrease in CHIKV infection with a half-maximal effective concentration (EC₅₀) of 48.8 nM. Digoxin treatment similarly decreases CHIKV infection of primary human synovial fibroblasts (HSFs) and Vero African green monkey kidney cells with EC₅₀s of 43.9 nM and 67.3 nM, respectively. Digoxin treatment significantly diminishes CHIKV infection in these cell types, with EC₅₀s of 16.2 ?M in ST2 cells and 23.2 ?M in C2C12 cells, values 330 and 475 times the EC₅₀ of Digoxin in U-2 OS cells. Cell viability is only modestly impaired at 24 h posttreatment with 1 ?M Digoxin, a dose 20 times the Digoxin EC₅₀ for CHIKV antiviral activity in these cells.

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