MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Eucalyptol

CAS No. : 470-82-6

MCE 站：Eucalyptol

产品活性：Eucalyptol 是 5-HT₃ 受体, 钾通道, TNF-α 和 IL-1β 的抑制剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Immunology/Inflammation  |  Apoptosis

作用靶点：5-HT Receptor  |  Potassium Channel  |  Interleukin Related  |  TNF Receptor

In Vitro: Eucalyptol inhibits 5-HT-evoked currents in oocytes expressing 5-HT₃ receptors with an IC₅₀ of 258 ?M. Eucalyptol (Cin) treatment significantly decreases the ROS level in Aβ_25-35 treated cells in a dose dependent manner. Eucalyptol treatment significantly decreases the NO level in Aβ_25-35 treated cells in a dose dependent manner (p<0.05 and p<0.01). Eucalyptol treatment also significantly decreases IL-1βlevel in Aβ_25-35 treated cells in a dose dependent manner (p<0.05 and p<0.01) as compare to Aβ_25-35 treated PC12 cells. IL-6 level is also attenuated by Eucalyptol in dose dependent manner (p<0.05 and p<0.01) as compare to Aβ_25-35 treated cells.

In Vivo: Results show that male and female rats treated with Eucalyptol (CIN) at the highest doses, 500 and 1000 mg/kg, have shown lower body weight than control group from the 7th to 50th day of treatment. The administration of Eucalyptol significantly reduces body weight gain of male rats (Eucalyptol 500 and 1000 mg/kg) and female rats (Eucalyptol 1000 mg/kg) in the first week of treatment. However, this reduction is followed by an increase in body weight of rats males and females treated with all doses of the second week until the end of treatment. For male rats, there is a significant increase of 6.93% in mean corpuscular volume (MCV) (Eucalyptol 1000 mg/kg) and of 43.54 and 38.98% in the platelet count (Eucalyptol 500 and 1000 mg/kg, respectively) and a decrease of 6.74 and 6.67% in mean corpuscular hemoglobin concentration (MCHC) (Eucalyptol 500 and 1000 mg/kg) and mean platelet volume (MPV) of 10.40, 10.60 and 15.73% (Eucalyptol 100, 500 and 1000 mg/kg, respectively), when compare to the control group.

相关产品：Resatorvid  |  Nigericin sodium salt  |  Disulfiram  |  BAPTA-AM  |  Shikonin  |  Tocilizumab  |  Fisetin  |  N-Formyl-Met-Leu-Phe  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Harmine  |  Glibenclamide  |  SCH-23390 hydrochloride  |  Adalimumab  |  R-7050  |  Tetrandrine  |  Puerarin  |  Amiodarone hydrochloride  |  Olanzapine  |  QNZ  |  GTS-21 dihydrochloride  |  TRAM-34  |  Ifenprodil tartrate  |  Thioridazine hydrochloride  |  Risperidone  |  Infliximab  |  Minoxidil  |  Diazoxide  |  20(S)-Ginsenoside Rg3  |  Senicapoc

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。