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Albiflorin

CAS No. : 39011-90-0

MCE 站：Albiflorin

产品活性：Albiflorin 是牡丹根中的主要成分，是一种具有神经保护作用的单萜糖苷。Albiflorin 还具有抗炎，抗氧化和镇痛作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: Albiflorin (50-200 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates glutamate (Glu)-induced reduction of cell viability.
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates Glu-induced reduction of nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio.
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment enhances phosphorylation of AKT and its downstream element GSK-3β.

In Vivo: Albiflorin (50?mg/kg; intraperitoneal injection; once a day; for 15 days; Wistar rats) treatment significantly increases the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery in rats. Albiflorin could inhibit the activation of p38 MAPK pathway in spinal microglia and subsequent upregulated IL-1β and TNF-α. Albiflorin displays remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-JNK (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord.

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