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Oleanolic Acid

CAS No. : 508-02-1

MCE 站：Oleanolic Acid

产品活性：Oleanolic Acid (Oleanic acid) 是一具有抗癌活性的天然化合物。

研究领域：Autophagy  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Autophagy  |  Endogenous Metabolite  |  HIV

In Vitro: Oleanolic acid (OA) suppresses the proliferation of lung cancer cells in both dose- and time-dependent manners, along with an increase in miR-122 abundance. CCNG1 and MEF2D, two putative miR-122 targets, are found to be downregulated by OA treatment . OA induces autophagy in normal tissue-derived cells without cytotoxicity. OA-induced autophagy is shown to decrease the proliferation of KRAS-transformed normal cells and to impair their invasion and anchorage-independent growth.

In Vivo: Mouse model experiments also demonstrat that OA suppresses the growth of KRAS-transformed breast epithelial cell MCF10A-derived tumor xenograft by inducing autophagy . Activation of MAPK pathways, including p-38 MAPK, JNK and ERK, is triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. OA induces p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibits Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event is indispensable for p38 MAPK-dependent apoptosis in cancer cells.It is also proved that p38 MAPK knockdown A549 tumors are resistant to the growth-inhibitory effect of OA. In OA-treated EAM mice the number of Treg cells and the production of IL-10 and IL-35 are markedly increased, while proinflammatory and profibrotic cytokines are significantly reduced.

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