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Schisandrin

CAS No. : 7432-28-2

MCE 站：Schisandrin

产品活性：Schisandrin (Schizandrin) 是一种从 Schisandra chinensis 的果实中分离出来的联苯环辛烯类木脂素。Schisandrin 具有抗氧化，保肝，抗癌和抗炎的活性。Schisandrin 还可以逆转大鼠的记忆障碍。

研究领域：Autophagy

作用靶点：Autophagy

In Vitro: Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.
Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.
Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC₅₀s of 42.0, 53.1, and 40.0 μM, respectively.
Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.

In Vivo: Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.
Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.

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