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Harringtonine

CAS No. : 26833-85-2

MCE 站：Harringtonine

产品活性：Harringtonine是一种天然的 Cephalotaxus 生物碱，可抑制蛋白质合成。Harringtonine 具有抗基孔肯雅 (CHIKV) 病毒的活性，EC₅₀ 为 0.24 μM。

研究领域：Anti-infection

作用靶点：Influenza Virus

In Vitro: Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation. Harringtonine displays potent inhibition of Chikungunya virus infection with an EC₅₀ of 0.24 μM. Harringtonine could inhibit other alphaviruses. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes.

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