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Luteolin

CAS No. : 491-70-3

MCE 站：Luteolin

产品活性：Luteolin (Luteoline), 一种黄酮类化合物，也是一种有效的 Nrf2 抑制剂。Luteolin 具有抗炎和抗癌特性，可在人类多种癌细胞系 (包括非小肺癌细胞) 中诱导细胞凋亡和细胞周期停滞，并抑制细胞转移和血管生成。

研究领域：NF-κB  |  Apoptosis  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Keap1-Nrf2  |  Apoptosis  |  Autophagy  |  Endogenous Metabolite

In Vitro: Luteolin (0-160 ?M; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner.
Luteolin (20-80 ?M; 24 hours; NCI-H460 cells) treatment causes an accumulation of cells in the S phase.
Luteolin (320-580 ?M; 48 hours; NCI-H460 cells) treatment induces apoptosis.
Luteolin (20-80 ?M; 24 hours; NCI-H460 cells) treatment increases the protein expression levels of apoptotic regulatory proteins, including the Bax/Bcl-2 ratio, in a concentration-dependent manner, however, only 80 ?M Luteolin inhibits the expression of Bad. Luteolin also decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner.

In Vivo: Luteolin (10-100?mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet.

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