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L-Chicoric Acid
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L-Chicoric Acid
CAS No. : 70831-56-0
MCE 站:L-Chicoric Acid
产品活性:L-Chicoric Acid ((-)-Chicoric acid) 是一种二咖啡酰酒石酸,是一种有效的,选择性的和可逆的 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,IC50 约为 100 nM。L-Chicoric Acid 还可抑制组织培养物中的 HIV-1 的复制。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:HIV Integrase | HIV
In Vitro: L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells.
The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound.
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热门标签:(-)-Chicoric acid