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Isocorynoxeine

CAS No. : 51014-29-0

MCE 站：Isocorynoxeine

产品活性：Isocorynoxeine，一种与钩藤碱有关的生物碱，对 5-HT_2A 受体介导的电流反应呈剂量依赖性抑制，IC₅₀ 为 72.4 μM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vitro: Isocorynoxeine inhibits 5-HT_2A receptor-mediated 5-HT currents. Isocorynoxeine prefer to interact with 5-HT_2A receptors rather than with 5-HT_2C receptors in the brain.Isocorynoxeine exhibits less potent inhibitory activity (with IC₅₀ values of > 100 μM) against the 5-HT_2C receptor-mediated response than the 5-HT_2A receptor-mediated response in oocytes. Isocorynoxeine dose-dependently and competitively inhibits 5-HT-evoked currents in Xenopus oocytes expressing 5-HT_2A receptors, but has less of a suppressive effect on those in oocytes expressing 5-HT_2C receptors.

In Vivo: The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01].

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