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3-Methyladenine

CAS No. : 5142-23-4

MCE 站：3-Methyladenine

产品活性：3-Methyladenine (3-MA) 是 PI3K 的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用。

研究领域：PI3K/Akt/mTOR  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：PI3K  |  Autophagy  |  Mitophagy  |  Endogenous Metabolite

In Vitro: 3-Methyladenine (0-10 mM; 0-48 hours) induces caspase-dependent cell death in HeLa cells in a time-and dose-dependent manner.
3-Methyladenine (5 mM; 24 hours) suppresses autophagy in HeLa cells under both glucose-free conditions and normal conditions.
3-Methyladenine (5 mM; 0-48 hours) suppresses conversion of LC3-I to LC3-II (autophagy markers) between 12hours and 48 hours, confirms the inhibitory effects on autophagy.
3-Methyladenine induces cell death is independent of autophagy inhibition.
3-Methyladenine significantly shortens the duration of nocodazole-induced-prometaphase arrest.
Note:
The recommended concentration of 3-MA is approximately 0.5-10 mM in cell culture. DMSO stock?solution is not recommended. We suggest that you can weigh out the amount of 3-MA you required before your experiment. Then please dissolve it in medium and sterilize with a 0.22 μm filter.

In Vivo: 3-Methyladenine (1.5?mg/100?g; intraperitoneal injection; 3-24?hours) treatment alleviates sodium taurocholate-induced severe acute pancreatitis (SAP) in rats at both 12 hours and 24?hours.
3-Methyladenine inhibits autophagy of pancreatic acinar cells in sodium taurocholate-tnduced SAP.
3-Methyladenine also shows inhibitory effects on PI3K/Akt signaling pathway and NF-κB signaling pathway in sodium taurocholate-induced SAP.

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