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Aucubin

CAS No. : 479-98-1

MCE 站：Aucubin

产品活性：Aucubin 是一种可从许多传统的草药中提取的环烯醚萜苷。Aucubin 具有许多生物学活性，例如抗氧化，抗衰老，抗炎，抗菌，抗纤维化，抗癌，保肝，神经保护和骨保护作用。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Aucubin (0.001-1 μg/mL; pretreated for 30 min) dose-dependently inhibits IgE-induced TNF-α and IL-6 production and expression in RBL-2H3 cells, with IC₅₀s of 0.101 and 0.19 μg/mL, respectively.
Aucubin (0.01 μg/mL; pretreated for 30 min) inhibits IgE-induced nuclear translocation of p65 subunit of NF-κB and degradation of IκBα in RBL-2H3 cells.
Aucubin (0.001-1 mM; 12 h) increases PC12 cellular viability and markedly inhbits H₂O₂-induced apoptotic cell death.

In Vivo: Aucubin (5 mg/kg; i.p. for 15 d) has antioxidant and pancreas-protective effects on rats with streptozotocin-induced diabetes.
Aucubin (40-200 mg/kg; a single i.p.) exhibits significant protective activity against α-amanitin intoxication in mice.
Aucubin (5 mg/kg/day; i.p. for 21 d) decreases the breathing frequency, increases the lung dynamic compliance, alleviates lung parenchymal fibrotic changes, and reduces the intrapulmonary collagen disposition and inflammatory injury of BLM-stimulated mice.

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