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Nobiletin

CAS No. : 478-01-3

MCE 站：Nobiletin

产品活性：Nobiletin 是一种来自柑橘皮的聚甲氧基黄酮，可改善记忆力丧失，是一种 RORs 激动剂。Nobiletin 可以降低分化的 C2C12 肌管中的 ROS 的水平，并具有抗炎和抗癌特性，包括抗血管生成，抗增殖，抗转移和诱导细胞凋亡。

研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Apoptosis  |  Autophagy

作用靶点：ROR  |  Reactive Oxygen Species  |  Apoptosis  |  Autophagy

In Vitro: Nobiletin (0-100 μM; 24 hours; U2OS and HOS cells) treatment progressively reduces protein expressions of MMP-2 and MMP-9. In U2OS and HOS cells, Nobiletin considerably reduces the phosphorylation of p-IKKα/β and p-IκBα, and protein expression of NF-κB in the cell nuclear fraction with the concomitant increase of the NF-κB expression in the cytosolic fraction. Nobiletin down-regulates the p-CREB and the SP-1 expressions in the nuclear fraction, whereas Nobiletin does not affect c-Jun and c-Fos expressions.
Nobiletin (0-100 μM; 24 hours; U2OS and HOS cells) treatment significantly reduces mRNA expressions of MMP-2 and MMP-9 dose-dependently in U2OS and HOS cells.

In Vivo: Nobiletin (0.1% of regular diet; oral administration; daily; for 20 weeks; male C57BL/6 mice) treatment restores glucose homeostasis and promots energy expenditure and circadian activity in aged mice.

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