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Hesperidin

CAS No. : 520-26-3

MCE 站：Hesperidin

产品活性：Hesperidin (Hesperetin 7-rutinoside) 是一种广泛存在于柑橘类水果中黄烷酮糖苷。Hesperidin 具有多种生物学特性，例如减少炎症介质并发挥重要的抗氧化作用。Hesperidin 还表现出抗肿瘤和抗过敏活性。

研究领域：Apoptosis  |  Autophagy  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Apoptosis  |  Autophagy  |  Reactive Oxygen Species  |  Endogenous Metabolite

In Vitro: Hesperidin (5-200 ?M; 24-72 h) induces potent cytotoxic effects in human osteosarcoma MG-63 cells.
Hesperidin (5-150 ?M; 48 h) induces early and late apoptosis in MG-63 cells.
Hesperidin (10-30 ?M) inhibits the activity of COX-2 and iNOS in a dose dependent manner in RAW 264.7 cells activated with LPS.
Hesperidin (0.1 μg/mL; 2 h) decreases the formation of MDA and intracellular ROS, including chondrocyte apoptosis.

In Vivo: Hesperidin (5-80 mg/kg; 2 weeks) significantly suppresses MG-63 tumor growth in mice.
Hesperidin (200 mg/kg; once daily for 28 d) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in a surgically-induced osteoarthritis (OA) rats.

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