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Shogaol

CAS No. : 555-66-8

MCE 站：Shogaol

产品活性：Shogaol ([6]-Shogaol) 是从生姜中分离的活性物质，具有多种生物活性，包括抗癌，抗炎和抗氧化。

研究领域：Autophagy

作用靶点：Autophagy

In Vitro: Shogaol ([6]-Shogaol) has anticancer activity against several cell lines. Shogaol ([6]-Shogaol) is identified to be cytotoxic in various cell lines, with KB (IC₅₀=7.4±2.2 μM) and HL60 (IC₅₀=7.9±2.0 μM) cells most susceptible to 6-shogaol. 6-shogaol (IC₅₀=8 μM) has much stronger growth inhibitory effects than 6-gingerol (IC₅₀=150 μM) on HCT-116 human colon cancer cells. Shogaol ([6]-Shogaol) stimulates phosphorylations of mitogen-activated protein kinases (MAPKs) such as ERK, JNK, and p38. Moreover, the 6-shogaol-induced expressions of Nrf2 and HO-1 are attenuated by treatments of SB202190 (a p38 specific inhibitor) and LY294002 (an Akt specific inhibitor).

In Vivo: The Shogaol ([6]-Shogaol) decreases the diethylnitrosamine (DEN)-mediated elevations of serum aspartate transaminase and alanine transaminase as well as the DEN-induced hepatic lipid peroxidation. Inductions of Nrf2 and HO-1 by 6-shogaol are also confirmed in the mice. The administration of Shogaol ([6]-Shogaol) to the mice also restores the DEN-reduced activity and protein expression of hepatic antioxidant enzymes such as superoxide dismutase, glutathione peroxidase and catalase.

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