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Stachydrine

CAS No. : 471-87-4

MCE 站：Stachydrine

产品活性：Stachydrine 是中国草本植物益母草的主要成分，用于促进血液循环和消除血瘀。Stachydrine 可抑制 NF-κB 信号通路。

研究领域：NF-κB  |  Metabolic Enzyme/Protease

作用靶点：NF-κB  |  Endogenous Metabolite

In Vitro: Stachydrine can inhibit the NF-κB signal pathway, and this may be related to the mechanism of anti-hypertrophic. Intervention of stachydrine significantly suppresses the level of p-IκB protein in the cytosol and NF-κB protein in the nucleus . Tissue factor mRNA is decreased in stachydrine-treated human umbilical vein endothelial cells. Stachydrine attenuates the decline of human umbilical vein endothelial cells viability and the increase of LDH activity induced by anoxia-reoxygenation. A dose dependent decrease in expression of mRNA, and protein levels are observed in stachydrine-treated human prostate cancer cells (PC-3 and LNcaP).

In Vivo: Stachydrine attenuates norepinephrine-induced cardiomyocyte hypertrophy and has potential protective effects against β-adrenergic receptor induced Ca²⁺ mishandling. Stachydrine treatment reduces the expressions of PERK, CHOP, and caspase-3 in the endoplasmic reticulum stress-related apoptosis pathway.

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