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Cynarin
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Cynarin
CAS No. : 30964-13-7
MCE 站:Cynarin
产品活性:Cynarin是具有多种生物活性的抗窒息剂,具有抗氧化,抗组胺和抗病毒等活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Anti-infection
作用靶点:Reactive Oxygen Species | Influenza Virus
In Vitro: Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD+, ABTS+, O2-, DPPH1, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. IC50 and Ki of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Antiviral Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Monomer Library | FDA Approved & Pharmacopeial Drug Library | Acetylcysteine | H2DCFDA | U0126-EtOH | Quercetin | Mitoqui mesylate | Tunicamycin | Vadimezan | Favipiravir | Curcumin | (-)-Epigallocatechin Gallate | L-Ascorbic acid | Diphenyleneiodonium chloride | Camptothecin | Mito-TEMPO | Aprotinin | Oseltamivir acid | GSK2795039 | Geldanamycin | Trolox | L-Glutathione reduced | Emricasan | Dimethyl fumarate | Rifampicin | Berberine chloride | Baicalein | Zinc Protoporphyrin | Mycophenolic acid | AG-1478 | Sodium dichloroacetate
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