MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Lycopene

CAS No. : 502-65-8

MCE 站：Lycopene

产品活性：Lycopene是番茄，番茄产品和其他红色水果和蔬菜中天然存在的类胡萝卜素; 具有抗氧化作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: Sufficient uptake of lycopene from the diet is necessary to benefit from its health promoting effects, since humans are unable to synthesise lycopene de novo. Lycopene significantly inhibits prostate and breast cancer cell growth at physiologically relevant concentrations of 1.25 μM and also causes a 30-40 % reduction in inhibitor of kappa B phosphorylation in the cells. Increased intake of lycopene, a major carotenoid in tomatoes, consumed as the all-trans-isomer attenuates alcohol induced apoptosis in 2E1 cells and reduces risk of prostate, lung and digestive cancers. Lycopene plays a role in the protection against photooxidative processes by acting as singlet molecular oxygen and peroxyl radicals scavengers and can interact synergistically with other antioxidants. Lycopene as a carotenoid can react with types of reactive oxygen species (ROS) in three different mechanisms: I) by electron-transfer, II) by hydrogen atom transfer or III) by adduct formation. Lycopene is able to deactivate singlet oxygen mainly by physical quenching. Lycopene decreases ROS production in SK-Hep-1 cells through inhibition of NADPH oxidase, brought about in the PKC pathway.

In Vivo: Lycopene is the most predominant carotenoid in human plasma and has a half life of about 2-3 days. Lycopene or processed tomatoes may lead to a reduction of intima-media thickness in vessel walls. Lycopene exerts protective effects against ATZ-induced toxicity in rat adrenal cortex. These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway. Lycopene improves hepatotoxicity acting as an antioxidant, reduces GSSG and regulates tGSH and CAT levels, reduces oxidative damage.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Acetylcysteine  |  H2DCFDA  |  Quercetin  |  Mitoqui mesylate  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  Diphenyleneiodonium chloride  |  Mito-TEMPO  |  GSK2795039  |  Trolox  |  L-Glutathione reduced  |  Dimethyl fumarate  |  Berberine chloride  |  Zinc Protoporphyrin  |  Sodium dichloroacetate  |  2-Methoxyestradiol  |  TPEN  |  Urolithin A  |  α-Vitamin E  |  Tempol  |  Piperlongumine  |  Coenzyme Q10  |  Asiaticoside  |  N-Acetylcysteine amide  |  D-α-Hydroxyglutaric acid disodium  |  Rhein  |  Elesclomol  |  Ellagic acid  |  Nobiletin  |  Procyanidin B2

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。