MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Neohesperidin dihydrochalcone

CAS No. : 20702-77-6

MCE 站：Neohesperidin dihydrochalcone

产品活性：Neohesperidin dihydrochalcone是一种合成的糖苷查耳酮，作为低热量人造甜味剂添加到各种食品和饮料中。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

In Vitro: Neohesperidin dihydrochalcone shows remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, neohesperidin dihydrochalcone is the most potent inhibitor of H₂O₂ and HOCl. Neohesperidin dihydrochalcone shows HOCl scavenging activity of 93.5% and H₂O₂ scavenging property of 73.5%. Neohesperidin dihydrochalcone shows extensive inhibitory effect especially on non-radical ROS H₂O₂ and HOCl with IC₅₀ values of 205.1, 25.5 μM. Neohesperidin dihydrochalcone is found to be an activator of porcine pancreatic alpha-amylase (PPA) with an IC₅₀ of 389 μM.

In Vivo: Neohesperidin dihydrochalcone administration results in significant reduction in activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Glycoside Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Monomer Library  |  FDA Approved & Pharmacopeial Drug Library  |  Flavonoids Library  |  Acetylcysteine  |  H2DCFDA  |  Quercetin  |  Mitoqui mesylate  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  Diphenyleneiodonium chloride  |  Mito-TEMPO  |  GSK2795039  |  Trolox  |  L-Glutathione reduced  |  Dimethyl fumarate  |  Berberine chloride  |  Zinc Protoporphyrin  |  Sodium dichloroacetate  |  Lycopene  |  2-Methoxyestradiol  |  TPEN  |  Urolithin A  |  α-Vitamin E  |  Tempol  |  Piperlongumine  |  Coenzyme Q10  |  Asiaticoside  |  N-Acetylcysteine amide  |  D-α-Hydroxyglutaric acid disodium  |  Rhein  |  Elesclomol  |  Ellagic acid  |  Nobiletin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。