MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Melatonin

CAS No. : 73-31-4

MCE 站：Melatonin

产品活性：Melatonin 是一种由松果体制成的激素，可激活褪黑激素受体。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一种新型的选择性 ATF-6 抑制剂，可通过 COX-2 下调诱导人肝癌细胞凋亡。Melatonin 通过内质网应激减弱palmitic acid-induced (HY-N0830)诱导的小鼠颗粒细胞凋亡。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Melatonin Receptor  |  Autophagy  |  Mitophagy  |  Endogenous Metabolite  |  Apoptosis

In Vivo: Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ_1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ_1-42. Melatonin treatment and lack of NLRP3^-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3^-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Human Endogenous Metabolite Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Monomer Library  |  FDA Approved & Pharmacopeial Drug Library  |  Gut Microbial Metabolite Library  |  MG-132  |  Rapamycin  |  3-Methyladenine  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  SB 203580  |  Acetylcysteine  |  Angiotensin II human  |  Deferoxamine mesylate  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Dexamethasone  |  Bortezomib  |  Metformin hydrochloride  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  U0126-EtOH  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  ATP  |  BAY 11-7082  |  Etoposide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。