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Hispidulin

CAS No. : 1447-88-7

MCE 站：Hispidulin

产品活性：Hispidulin是具有广泛生物活性的天然黄酮。 Hispidulin是Pim-1的抑制剂，IC₅₀值为2.71 μM。

研究领域：JAK/STAT Signaling

作用靶点：Pim

In Vitro: Hispidulin induces cell death in a dose- and time-dependent manner in HepG2 cells. Hispidulin induces apoptosis through mitochondrial dysfunction, which is characterized by decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential and increased release of cytochrome C and activated capase-3.

In Vivo: Hispidulin shows significant inhibitory effect on mice tumor size. Hispidulin treatment effectively prevents ovariectomy-induced body weight loss and attenuates ovariectomy-induced bone loss. Hispidulin treatment also decreases trabecular spacing in ovariectomy mice. Intraperitoneally administering hispidulin(10 or 50mg/ kg) to rats 30 min before intraperitoneally injecting kainic acid (15mg/kg) increases seizure latency and decreases seizure score. In addition, hispidulin substantially attenuates kainic acid-induced hippocampal neuronal cell death, and this protective effect is accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Traditional Chinese Medicine Monomer Library  |  Flavonoids Library  |  Anti-Pancreatic Cancer Compound Library  |  PIM-447 dihydrochloride  |  Pim1/AKK1-IN-1  |  TCS-PIM-1-4a  |  TCS PIM-1 1  |  Quercetagetin  |  M-110  |  SMI-16a  |  CK2/ERK8-IN-1  |  CK2/PIM1-IN-1  |  CX-6258 hydrochloride  |  R8-T198wt

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