当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > 天然产物 > Puromycin dihydrochloride
Puromycin dihydrochloride
企业档案
会员类型:会员
已获得易推广信誉 等级评定
(0 -40)基础信誉积累,可浏览访问
(41-90)良好信誉积累,可接洽商谈
(91+ )优质信誉积累,可持续信赖
易推广会员:8年
最后认证时间:
注册号: 【已认证】
法人代表: 【已认证】
企业类型:生产商 【已认证】
注册资金:人民币万 【已认证】
产品数:91228
参观次数:11366929
联系我们
MedChemExpress
电话:021-58955995
联系人:客服部 (请说明是在易推广看到的!谢谢)
手机:13611715263
邮编:201203
邮箱:sales@medchemexpress.cn
地址:上海上海
详细内容
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Puromycin dihydrochloride
CAS No. : 58-58-2
MCE 站:Puromycin dihydrochloride
产品活性:Puromycin dihydrochloride (CL13900 dihydrochloride) 是一种氨基核苷类抗生素,抑制蛋白合成 (protein synthesis)。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Puromycin blocks protein synthesis after aminoacyl-sRNA formation, and at the same time it leads to the accumulation of small peptides. Both of these effects appear to be due to the splitting of ribosome-bound peptidyl-sRNA,4 which results in release of incomplete peptide chains..
Puromycin, an analog of the 3' end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin has two modes of inhibitory action. The first is by acting as an acceptor substrate which attacks peptidyl-tRNA in the P site to form a nascent peptide. The second is by competing with aminoacyl-tRNA for binding to the A' site.
When used in minimal amounts, puromycin incorporation in neosynthesized proteins reflects directly the rate of mRNA translation in vitro. Puromycin immunodetection is an advantageous alternative to radioactive amino acid labeling. It allows the direct evaluation of translation activity in single cells by immunofluorescence microscopy and in heterogenous populations of cells by fluorescenceactivated cell sorting.
相关产品:Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Natural Product Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Glycoside Compound Library | Antibacterial Compound Library | Anti-COVID-19 Compound Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Alkaloids Library | Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Cycloheximide | Chloroquine | Staurosporine | Dexamethasone | Doxycycline (hyclate) | Actinomycin D | Cyclosporin A | G-418 disulfate | 5-Azacytidine | Etoposide | Mitomycin C | CCCP | Nigericin sodium salt | Brefeldin A | Wortmannin | Resveratrol | Tunicamycin | Bleomycin sulfate | Hygromycin B | Tacrolimus | Ionomycin | Vancomycin hydrochloride | Streptozocin | Tanespimycin | Oligomycin A | Anisomycin
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
热门标签:CL13900 dihydrochloride