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Citric acid

CAS No. : 77-92-9

MCE 站：Citric acid

产品活性：Citric acid 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是天然防腐剂和食品添加剂。

研究领域：Apoptosis  |  Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Bacterial  |  Endogenous Metabolite  |  Antibiotic

In Vitro: Citric acid induces apoptosis through the mitochondrial pathway in the human keratinocyte cell line HaCaT. It inhibits proliferation of HaCaT cells in a dose-dependent manner, but also induces apoptosis and cell cycle-arrest at the G2/M phase (before 24 h) and S phase (after 24 h).

In Vivo: Citric acid is found in all animal tissues as an intermediary substance in oxidative metabolism. The administration of citric acid (1–2?g/kg) attenuates LPS-induced elevations in brain MDA, nitrite, TNF-α, GPx, and PON1 activity. In the liver, nitrite is decreased by 1?g/kg citric acid. Citric acid (1-2?g/kg) decreases brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. Citric acid supplementation increases intestinal calcium and phosphorus absorption and the retention/intake ratio only in rats fed the 1% Ca diet. Citric acidsupplementation together with a calcium-rich diet allows to obtain an increased retention of calcium and phosphorus in bone. The prolonged administration of calcium citrate supplements may therefore help to increase bone mineral concentration. Oral administration of citric acid ameliorates ketosis and protects against the development of diabetic complications in an animal model of type 1 diabetes.

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