MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

9-amino-CPT

CAS No. : 91421-43-1

MCE 站：9-amino-CPT

产品活性：9-amino-CPT (9-amino-20(S)-camptothecin) 是拓扑异构酶I的抑制剂，具有有效地抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: In human breast (MCF-7), bladder (MGH-U1), and colon (HT-29) cancer cell lines, 9-Aminocamptothecin cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-Aminocamptothecin concentrations exceeds a threshold of 2.7 nm. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC₅₀ values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure.

In Vivo: 9-amino-CPT (9-amino-20(S)-camptothecin) inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression. 9-amino-CPT (9-amino-20(S)-camptothecin) is well tolerated at all doses, with no toxic death or weight loss of more than 10% observed in any group. 9-amino-CPT (9-amino-20(S)-camptothecin) induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective. The results with this pre-clinical model support the evaluation of 9-Aminocamptothecin as antileukemic agent in a phase I trial in patients with AML.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Alkaloids Library  |  Anti-Blood Cancer Compound Library  |  Doxorubicin hydrochloride  |  Etoposide  |  Irinotecan  |  SN-38  |  Camptothecin  |  Topotecan Hydrochloride  |  Epirubicin hydrochloride  |  Daunorubicin hydrochloride  |  Exatecan mesylate  |  Suramin sodium salt  |  Berberine chloride  |  Mitoxantrone  |  Betulinic acid  |  EIDD-1931  |  Idarubicin hydrochloride  |  Aldoxorubicin  |  Banoxantrone dihydrochloride  |  β-Lapachone  |  Teniposide  |  Hycanthone  |  Pirarubicin  |  Bisantrene  |  Aclacinomycin A hydrochloride  |  Amsacrine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。