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Asiaticoside
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Asiaticoside
CAS No. : 16830-15-2
MCE 站:Asiaticoside
产品活性:Asiaticoside 是从积雪草中分到的三萜皂苷化合物,在瘢痕疙瘩成纤维细胞中,通过活化 Smad7,抑制 TGF-βRI 和 TGF-βRII,抑制 TGF-β/Smad 信号通路;Asiaticoside 具有抗氧化、抗炎、抗溃疡等功效。
研究领域:Stem Cell/Wnt | TGF-beta/Smad | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis
作用靶点:TGF-beta/Smad | Reactive Oxygen Species | Apoptosis | Endogenous Metabolite
In Vitro: Asiaticoside (0, 100, 250, and 500 mg/L) dose-dependently inhibits keloid fibroblasts proliferation. Asiaticoside (100, 250, and 500 mg/L) decreases the expression of collagen protein and mRNA, reduces the expression of TGF-bRI, TGF-bRII protein, and mRNA, increases the expression of Smad7, but does not affect Smad2, Smad3, Smad4, phosphorylated Smad2, and phosphorylated Smad3 in keloid fibroblasts. Asiaticoside (12.5 and 50, and 25 and 50 ?g/mL) prevents endothelial cells from hypoxia-induced inhibition of cell viability and NO production. Asiaticoside (50 ?g/mL) also protects endothelial cells from hypoxia-induced apoptosis and upregulates and phosphorylation of AKT/eNOS in hypoxia-exposed HPAECs.
In Vivo: Asiaticoside (50 mg/kg daily) blocks the development of hypoxic pulmonary hypertension (PH), cardiovascular remodeling and endothelial cell injury in rats with pulmonary hypertension. Asiaticoside (5, 15 or 45 mg/kg, p.o.) improves the learning and memory deficit, protects hippocampi against the impairment, decreases Aβ deposits in the hippocampus, and ameliorates impaired subcellular structure in rats treated with Aβ oligomers.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Wnt/Hedgehog/Notch Compound Library | Natural Product Library | Anti-Cancer Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Monomer Library | FDA Approved & Pharmacopeial Drug Library | MG-132 | Rapamycin | 3-Methyladenine | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | H2DCFDA | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | ATP | BAY 11-7082 | Etoposide | Mitomycin C | CCCP | Retinoic acid | DAPT
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