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Bradykinin (1-5)

CAS No. : 23815-89-6

MCE 站：Bradykinin (1-5)

产品活性：Bradykinin (1-5) 是 Bradykinin 的主要稳定代谢物，由血管紧张素转换酶 (ACE) 经蛋白水解作用形成。

研究领域：GPCR/G Protein

作用靶点：Bradykinin Receptor

In Vivo: Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED₅₀ of 183±2 pmol/min.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Endocrinology Compound Library  |  Neurotransmitter Receptor Compound Library  |  Bradykinin  |  Icatibant  |  [Des-Arg9]-Bradykinin acetate  |  ELN-441958  |  Lys-[Des-Arg9]Bradykinin TFA  |  Bradykinin (2-9)  |  Bradykinin (1-6)  |  Retrobradykinin  |  [Hyp3]-Bradykinin  |  Bradykinin (1-3)  |  Bradykinin (1-7)  |  FR167344 free base

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