当前位置: 易推广 > 生物试剂/抗体/细胞 > 生化试剂 > 其他 > MedChemExpress > 产品展示 > 多肽产品 > Thyrotropin-Releasing Hormone (TRH), Free Acid
Thyrotropin-Releasing Hormone (TRH), Free Acid
企业档案
会员类型:会员
已获得易推广信誉 等级评定
(0 -40)基础信誉积累,可浏览访问
(41-90)良好信誉积累,可接洽商谈
(91+ )优质信誉积累,可持续信赖
易推广会员:8年
最后认证时间:
注册号: 【已认证】
法人代表: 【已认证】
企业类型:生产商 【已认证】
注册资金:人民币万 【已认证】
产品数:91228
参观次数:11440724
联系我们
MedChemExpress
电话:021-58955995
联系人:客服部 (请说明是在易推广看到的!谢谢)
手机:13611715263
邮编:201203
邮箱:sales@medchemexpress.cn
地址:上海上海
详细内容
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Thyrotropin-Releasing Hormone (TRH), Free Acid
CAS No. : 24769-58-2
MCE 站:Thyrotropin-Releasing Hormone (TRH), Free Acid
产品活性:Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH)是促甲状腺激素释放激素一种生理代谢产物。
研究领域:Others
作用靶点:Others
In Vitro: TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions. TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.
相关产品:Bioactive Compound Library Plus | PEG300 | SBE-β-CD | Corn oil | Tween 80 | Polyethylene glycol 12-hydroxystearate | JC-1 | Lipopolysaccharides | DTT | (2-Hydroxypropyl)-β-cyclodextrin | Methyl-β-cyclodextrin | CFSE | Digitonin | D-Luciferin potassium salt | Thiazolyl Blue | Biotin | 3X FLAG peptide TFA | Monocrotaline | Nile Red | Auxinole | Tocofersolan | FLAG peptide | IPTG | Yoda 1 | Cremophor EL | GsMTx4 TFA | Propidium Iodide | DAPI dihydrochloride | Calcein-AM | Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
热门标签:TRH-OH