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β-Amyloid (10-35), amide

CAS No. : 181427-66-7

MCE 站：β-Amyloid (10-35), amide

产品活性：β-Amyloid (10-35), amide 是一种含有 26 个氨基酸的多肽，由 β-Amyloid 肽的 10-35 残基组成。β-Amyloid (10-35) 是阿尔兹海默症淀粉样斑块 (Alzheimer’s disease) 的主要组成成分。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ_(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils.

相关产品：Deferoxamine mesylate  |  DAPT  |  β-Amyloid (25-35)  |  FPS-ZM1  |  Colivelin TFA  |  Rutin  |  β-Amyloid (1-42), human TFA  |  20(S)-Ginsenoside Rg3  |  β-Amyloid (1-40)  |  Tolcapone  |  Geniposide  |  Ginsenoside Rg1  |  Licochalcone B  |  β-Amyloid (1-42), rat TFA  |  Semagacestat  |  Latrepirdine dihydrochloride  |  β-Amyloid (42-1), human  |  Dihydroergocristine mesylate  |  Ginsenoside Re  |  Ginsenoside Rg2  |  Hematoxylin  |  Notoginsenoside R1  |  Hoechst 34580 tetrahydrochloride  |  Phenserine  |  Frentizole  |  Tramiprosate  |  LX2343  |  Scyllo-Inositol  |  Aftin-4

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