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Engeletin

CAS No. : 572-31-6

MCE 站：Engeletin

产品活性：Engeletin 是从 hymenaea martiana 中得到的黄酮苷类物质，能够抑制 NF-κB 信号通路的激活，具有抗炎、镇痛、利尿、消肿、抗菌等作用。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation.

In Vivo: Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.

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