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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

CAS No. : 1366000-58-9

MCE 站：Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

产品活性：Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是一种含 28 个氨基酸的激素，由心脏产生并分泌，以响应心脏损伤和机械拉伸。ANP (1-28) 抑制内皮素-1 (endothelin-1) 分泌。

研究领域：GPCR/G Protein

作用靶点：Endothelin Receptor

In Vitro: Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human ¹²⁵I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.

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