MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Genkwanin

CAS No. : 437-64-9

MCE 站：Genkwanin

产品活性：Genkwanin (芫花素) 是一种O-甲基化黄酮，有抗炎活性。

研究领域：Anti-infection

作用靶点：Virus Protease

In Vitro: Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Immunology/Inflammation Compound Library  |  Natural Product Library  |  Antiviral Compound Library  |  Medicine Food Homology Compound Library  |  Traditional Chinese Medicine Monomer Library  |  Flavonoids Library  |  4-Phenylbutyric acid  |  Glycyrrhizic acid  |  Aspirin  |  Ebselen  |  Dynasore  |  Artesunate  |  Brequinar  |  PF429242 dihydrochloride  |  Carmofur  |  Lycorine hydrochloride  |  Hinokitiol  |  NH125  |  Phenytoin  |  Probucol  |  alpha-Mangostin  |  Oroxylin A  |  Theaflavin 3,3'-digallate  |  Rupintrivir  |  Schisandrin A  |  4E2RCat  |  (-)-Epicatechin gallate  |  A2ti-1  |  Angelicin  |  Danthron  |  Bergenin  |  L-Lysine  |  ML188  |  Schisandrin C

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。