MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Paraxanthine

CAS No. : 611-59-6

MCE 站：Paraxanthine

产品活性：Paraxanthine，caffeine的代谢物，可通过刺激Ryanodine受体通道来抑制多巴胺能细胞的死亡。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH⁺neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH⁺neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH⁺ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase).

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  Human Endogenous Metabolite Compound Library  |  Alkaloids Library  |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Docetaxel  |  Estradiol  |  Melatonin  |  Nicotinamide  |  Cytarabine  |  Isoprenaline hydrochloride  |  Prostaglandin E2  |  Acetaminophen  |  (-)-Epigallocatechin Gallate  |  β-Nicotinamide mononucleotide  |  Calcitriol  |  DHEA  |  Liothyronine  |  NAD+  |  Luteolin  |  Thymidine  |  Docosahexaenoic Acid  |  Kaempferol  |  Palmitic acid  |  Cyclopamine  |  Genistein  |  L-Glutathione reduced  |  Progesterone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。