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GLP-1(7-36), amide

CAS No. : 107444-51-9

MCE 站：GLP-1(7-36), amide

产品活性：GLP-1(7-36), amide 是刺激胰岛素分泌的生理性肠降血糖素。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: The sequence of Glucagon-Like Peptide after residue 7 shows similarities to glucagon and to other biologically active members of the secretin peptide family, particularly glucose-dependent insulinotropic peptide (GIP). This sequence has been especially well preserved, showing 66% nucleotide homology with GLP-1 in the proglucagon of the very primitive anglerfish. This 7-36 sequence of GLP-1 is a potent insulin-releasing peptide in vitro. Glucagon-Like Peptide (GLP) I (7-36), amide is a product of the tissue-specific post-translational processing of the glucagon precursor. It is released postprandially from intestinal endocrine L cells and stimulates insulin secretion. DPP IV is the main degradation enzyme for GLP-l(7 - 36)amide in human serum. Dipeptidyl-peptidase IV can initiate the metabolism of GIP and GLP-1(7-36)amide in human serum.

In Vivo: Glucagon-Like Peptide (GLP) I (7-36), amide is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Exogenous GLP-1 (7-36 amide) is an effective means of normalizing fasting plasma glucose concentrations in poorly-controlled Type 2 diabetic subjects. Exogenously administered GLP-1-(7–36)amide is extremely labile in vivo, with more than 80% being cleaved into GLP-1-(9–36)amide after sc or iv administration.

相关产品：Exendin-4  |  Liraglutide  |  Glucagon (1-29), bovine, human, porcine  |  Avexitide  |  Adomeglivant  |  GLP-1(7-37)  |  GLP-1(7-36), amide acetate  |  BETP  |  GLP-2(1-33)(human)  |  GRA Ex-25  |  NNC-0640  |  Cotadutide acetate  |  Glucagon-like peptide 1 (1-37), human TFA  |  Taspoglutide  |  GLP-1 moiety from Dulaglutide  |  Glucagon receptor antagonists-3  |  GLP-1(9-36)amide  |  GLP-2(3-33)  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  GLP-1(28-36)amide  |  GLP-1(32-36)amide  |  GLP-1R Antagonist 1  |  Glucagon receptor antagonists-1  |  GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  HAEGTFT

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