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Transcrocetinate disodium

CAS No. : 591230-99-8

MCE 站：Transcrocetinate disodium

产品活性：Transcrocetinate disodium 从藏红花 (Crocus sativus L.) 中提取的，是一种高亲和力的 NMDA 受体拮抗剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: Transcrocetinate (Transcrocetin, trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 ?M) reveal no negative significant changes in cellular viability. Transcrocetinate at 10 ?M level does not change viability while higher concentrations (40-160 ?M) reduces significantly cellular viability.

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