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Ammonium glycyrrhizinate

CAS No. : 53956-04-0

MCE 站：Ammonium glycyrrhizinate

产品活性：Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) 具有抗炎、抗过敏、抗胃溃疡、抗肝炎等药理活性。

研究领域：Others

作用靶点：Others

In Vivo: The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30mg/kg) administration. Pretreatment with MAG (10 and 30mg/kg) efficiently reduces the production of TNF-?? and IL-1??. MAG (10, 30mg/kg) significantly decreases NF-??B p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces I??B-?? protein expression compared with the control group, whereas MAG (10 and 30mg/kg) significantly increased I??B-?? expression, compared with the LPS group.
Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries.

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