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Pyridoxylamine dihydrochloride

CAS No. : 524-36-7

MCE 站：Pyridoxylamine dihydrochloride

产品活性：Pyridoxylamine dihydrochloride 是糖基化终产物 (AGE) 和脂质化终产物 (ALE) 抑制剂，可防止糖尿病引起的视网膜血管病变。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Pyridoxylamine (PM), a member of the B₆ vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.

In Vivo: Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynal adducts on protein in Zucker rats in vivo.

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