MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Glycomimetic Library

MCE 站：Glycomimetic Library

A specially synthesized set of 2,718 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

Description & Advantages:

?   A specially synthesized set of 2,718 compounds able to mimic glycosides and their interaction with proteins.

?   Privileged core fragments and side chain functionalities: cyclic amino alcohols, cyclic glycols; O,N-containing aliphatic rings; polyalcohols.

?   We suppose the library application would identify new attractive chemotypes which correspond to drug-/lead-like criteria and on the other hand participate in key interactions similar to glycoside binding in the active site of the targets.

?   Nature-likeness scoring algorithm: Taverna 2.5 workbench, similarity to available NP databases.

?   MedChem structural filters, removal of common and trivial chemotypes: PAINS, REOS, Elli Lily rules and strict Enamine filters.

?   Structurally diverse.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds can be readily followed with analogues either from stock or from new syntheses.

?   Databases and compounds are provided by Enamine.

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。