MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Napsagatran hydrate

CAS No. : 159668-20-9

MCE 站：Napsagatran hydrate

产品活性：Napsagatran hydrate 是一种新型的特异性凝血酶 (thrombin) 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Thrombin

In Vitro: Napsagatran (Ro 46-6240), the selective thrombin inhibitor, induces a dose-dependent prolongation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT) that is evident 15 min after administration of the bolus of Napsagatran. Napsagatran also reduces the time to reperfusion in a dose-dependent manner and delays or prevents reocclusion. The decreasing intracellular amount and efflux of compound from the cells into the medium is measured. The measured CL_int,efflux values are 0.13±0.06, 3.2±0.6, 10.1±2.3, and 110±2.8 for Digoxin, Fexofenadine, Napsagatran, and Rosuvastatin, respectively, thus representing drugs with a >800-fold range of efflux rates.

In Vivo: After the first hour of drug administration (from 0 to 60 min), the incorporated radioactivity into thrombi increased from baseline by 73±13, 67±22 and 32±10% in placebo, AP-1 and Napsagatran-treated rabbits, respectively. Statistical analysis confirm that thrombus growth in the placebo and AP-1 treated rabbits is not different. In contrast, reduction of ¹²⁵I-fibrinogen incorporation by Napsagatran is statistical different from the placebo group (P<0.01).

相关产品：Heparin sodium salt  |  Thrombin (MW 37kDa)  |  AEBSF hydrochloride  |  Dabigatran  |  Bivalirudin TFA  |  Argatroban monohydrate  |  Metolazone  |  TP508 TFA  |  Ximelagatran  |  Sfllrnpndkyepf  |  Odiparcil  |  Protamine sulfate  |  Inogatran  |  Melagatran  |  NQ301  |  Razaxaban hydrochloride  |  RWJ-445167  |  Sofigatran  |  Thrombin Inhibitor 2  |  Desethyl KBT-3022  |  OM-189  |  Thrombin inhibitor 1

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。