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Risarestat

CAS No. : 79714-31-1

MCE 站：Risarestat

产品活性：Risarestat (CT-112)是一种醛糖还原酶抑制剂，开发用于糖尿病并发症的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Aldose Reductase

In Vivo: Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution. Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns². Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm². Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Diabetes Related Compound Library  |  Isoliquiritigenin  |  Epalrestat  |  Fidarestat  |  Ranirestat  |  Ponalrestat  |  Tolrestat  |  Lidorestat  |  Aldose reductase-IN-1  |  Alrestatin  |  Imirestat  |  Poliumoside  |  Sorbinil  |  6-Methoxytricin  |  Quercetin 3-gentiobioside

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