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SR-31747 free base

CAS No. : 132173-06-9

MCE 站：SR-31747 free base

产品活性：SR-31747 free base 是一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 free base 通过抑制固醇异构酶来阻止细胞增殖。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Sigma Receptor

In Vitro: SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.

In Vivo: In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED₅₀, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.

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