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TAS-115

CAS No. : 1190836-34-0

MCE 站：TAS-115

产品活性：TAS-115 是一种有效的 VEGFR 和 c-Met/HGFR 抑制剂，能够抑制 rVEGFR2 和 rMET 的活性，IC₅₀ 值分别为 30 和 32 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：VEGFR  |  c-Met/HGFR

In Vitro: TAS-115 is ATP antagonism with inhibition constant (K_i) values against rVEGFR2 and rMET of 12 and 39 nM, respectively. AS-115 inhibits the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 induces less damage in various normal cells than do other VEGFR inhibitors. TAS-115 does not affect the growth of PC-9 or HCC827 cells at concentrations less than 10 μM; however, the combined use of TAS-115 with erlotinib reverses HGF-induced resistance in the cell lines in a concentration-dependent manner. TAS-115 inhibits VEGF production by cancer cells and endothelial proliferation.

In Vivo: TAS-115 (50 mg/kg/d) completely prevents tumor growth during the treatment period. TAS-115 (200 mg/kg/d) induces a 48% regression from the initial tumor volume in MET-amplified human cancer transplanted models. The estimated 50% effective dose (ED₅₀) of TAS-115 in this model is 8 mg/kg/d. TAS-115 significantly prolongs survival of these mice when administered at doses of 50 or 200 mg/kg/d. TAS-115 inhibits angiogenesis in PC-9/HGF tumors in vivo. Moreover, the doublet erlotinib and TAS-115 successfully inhibit PC-9/HGF tumor growth and delay tumor regrowth associated with sustained tumor vasculature inhibition even after cessation of the treatment.

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