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S-2474

CAS No. : 158089-95-3

MCE 站：S-2474

产品活性：S-2474 是 COX-2 和 5-lipoxygenase (5-LO) 的抑制剂，在人完整的细胞中，对 COX-2 和 COX-1 的 IC₅₀ 值分别为 11 nM 和 27 μM，为一种非甾体抗炎药。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：COX  |  Lipoxygenase

In Vitro: S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC₅₀ =26±12?nM). S-2474 (10?μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC₅₀=69.8±21.9?nM). S-2474 (10?μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons. S-2474 significantly prevents neurons from undergoing sPLA₂-IIA-induced cell death. S-2474 completely ameliorates sPLA₂-IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA₂-IIA-induced generation of PGD2. S-2474 inhibits sPLA₂-IIA-induced neuronal cell death in a concentration-dependent manner (IC₅₀ = 94 nM).

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