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CNDAC

CAS No. : 135598-68-4

MCE 站：CNDAC

产品活性：CNDAC 是 sapacitabine 的有效代谢物，为一种核苷类似物。

研究领域：Cell Cycle/DNA Damage

作用靶点：Nucleoside Antimetabolite/Analog

In Vitro: CNDAC-induced SSBs can be repaired by the transcription-coupled nucleotide excision repair pathway, whereas lethal DSBs are mainly repaired through homologous recombination. Deficiency in two Rad51 paralogs, Rad51D and XRCC3, greatly sensitize cells to CNDAC. The Rad51D-null cell line is approximately 50-fold more sensitive to CNDAC (IC₅₀=0.006 ?M) compared to 51D1.3, the Rad51D-repleted line (IC₅₀=0.32 ?M). CNDAC shows inhibitory activity against HL-60 and THP-1 cells with IC₅₀s of 1.58 ?M and 0.84 ?M. CNDAC (10?μM) results in a significant drop in cell survival compared to the untreated on days 4, 7, and 14. CNDAC is more effective at reducing viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line, which is defined as displaying resistance to ara-C. CNDAC induces DSBs, which are products of replication, rather than a consequence of induction of apoptosis. CNDAC causes DNA damage, and DNA-PK and ATR are dispensable for cell survival. CNDAC exhibits potent activity against human fibroblasts deficient in ATM or transfected with an empty vector, approximately 30-fold more than cells repleted with full-length ATM cDNA, with IC₅₀s of 0.01 μM and 0.3 μM, respectively. CNDAC-induced DNA damage is repaired through the homologous recombination pathway.

相关产品：5-Fluorouracil  |  Gemcitabine  |  Decitabine  |  5-Azacytidine  |  Cytarabine  |  5-BrdU  |  Fludarabine  |  Capecitabine  |  Ganciclovir  |  Adenosine  |  Dacarbazine  |  Floxuridine  |  Carmofur  |  Raltitrexed  |  8-Azaguanine  |  Trifluridine/tipiracil hydrochloride mixture  |  Clofarabine  |  Stavudine  |  Doxifluridine  |  Tegafur  |  Vidarabine  |  N6,N6-Dimethyladenosine  |  6-Mercaptopurine hydrate  |  Sapacitabine  |  Nelarabine

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