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CTS-1027

CAS No. : 193022-04-7

MCE 站：CTS-1027

产品活性：CTS-1027 是一种有效的 MMP 抑制剂，能够作用于 MMP2 和 MMP13，IC₅₀ 值分别为 0.3 nM 和 0.5 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP

In Vivo: CTS-1027 significantly reduces the hepatocyte apoptosis, features of cholestatic liver injury, amd markers of hepatic fibrogenesis in the BDL mouse. CTS-1027 improves overall animal survival following 14 days of BDL in mice. In male animals treated for 8 weeks the terminal plasma concentration of RS-130830 is 311±45 nM. Treatment of male mice with RS-130830 for 8 weeks causes an 89% increase in plasma triglyceride concentration, but there is no corresponding effect in female mice treated for 12 weeks. The plaque lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks.

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