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SRT 1720 Hydrochloride

CAS No. : 2060259-60-9

MCE 站：SRT 1720 Hydrochloride

产品活性：SRT 1720 Hydrochloride 是选择性的 SIRT1 激活剂，EC₅₀为 0.10 μM，对 SIRT2 和 SIRT3 的作用较弱。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶点：Sirtuin  |  Autophagy

In Vitro: SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300.

In Vivo: SRT 1720 (10, 30, 100 mg/kg, p.o.) treatment significantly reduces fasting blood glucose to near normal levels in Lep^ob/ob mice.
SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1.
SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Diabetes Related Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Resveratrol  |  Selisistat  |  Nicotinamide  |  Nicotinamide riboside chloride  |  3-TYP  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  UBCS039  |  Sirtinol  |  CAY10602  |  AGK2  |  AK-7  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482  |  Ganoderic acid D  |  PROTAC Sirt2 Degrader-1  |  SRT 2183  |  Dihydrocoumarin  |  Ginkgolide C  |  Inauhzin  |  SIRT-IN-3  |  JFD00244  |  Gardenia yellow  |  Agrimol B  |  Sirtuin modulator 1  |  Ophiopogonin D'  |  Scopolin

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