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Riociguat

CAS No. : 625115-55-1

MCE 站：Riociguat

产品活性：Riociguat (BAY 632521) 是一种可口服的可溶性鸟苷酸环化酶 (sGC) 刺激剂，常用于研究肺动脉高压症。

研究领域：GPCR/G Protein

作用靶点：Guanylate Cyclase

In Vitro: Riocigua stimulates the recombinant sGC concentration dependently from 0.1 to 100?μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism.?Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes.

In Vivo: Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature in chronic treatment of hypoxic mice and MCT-injected rats.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Lificiguat  |  Linaclotide  |  Methylene Blue  |  Cinaciguat  |  BAY 41-2272  |  NS-2028  |  ODQ  |  Guanylin(human) TFA  |  BAY 41-8543  |  BAY 60-2770  |  (4-Acetamidocyclohexyl) nitrate

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